Wege, Anja K. and Huber, Barbara and Wimmer, Nadin and Maennel, Daniela N. and Hehlgans, Thomas (2014) LT beta R expression on hematopoietic cells regulates acute inflammation and influences maturation of myeloid subpopulations. INNATE IMMUNITY, 20 (5). pp. 461-470. ISSN 1753-4259, 1753-4267
Full text not available from this repository. (Request a copy)Abstract
Lymphotoxin beta-receptor (LT beta R) is involved in the formation and maintenance of secondary lymphoid structures, as well as in the regulation of inflammatory responses. Because LT beta R lymphoid structure formation continues to develop in infants, we compared two different chimera models: one using adult mice and the other using a transplantation model of neonatal mice. To elucidate the function of LT beta R on lymphoid and non-lymphoid cells, we generated bone marrow chimeras on the wild type C57Bl/6 and the LT beta R-deficient (LT beta R- /-) background, and reconstituted the mice with bone marrow cells reciprocally. These chimeric mice were analyzed in the experimental model of acute dextran sulfate sodium-induced colitis. Interestingly, both models revealed not only equal reconstitution levels but also similar immunological responses: LT beta R expression on stromal cells is essential for lymph node formation, whereas LT beta R on hematopoietic cells is crucial for a decrease in inflammation. In addition, mice lacking LT beta R on hematopoietic cells revealed (a) an increase of immature granulocytic cells in the spleen and (b) a reduced proportion of myeloid cells in peripheral blood and spleen expressing CD11b(+)Ly6C(+)Ly6G(-) (myeloid-derived suppressor cells expression profile). In conclusion, LT beta R expression on hematopoietic cells seems to be involved in the down-regulation of acute inflammatory reactions paralleled by the appearance of immature myeloid cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCED INTESTINAL INFLAMMATION; LYMPHOTOXIN-BETA; SUPPRESSOR-CELLS; RECEPTOR ACTIVATION; B-LYMPHOCYTES; IMMUNE SUPPRESSION; LYMPHOID ORGANS; DENDRITIC CELLS; T-LYMPHOCYTES; NITRIC-OXIDE; Bone marrow chimera; dampening inflammation; DSS-induced colitis; LT beta R; MDSC |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Oct 2019 12:05 |
| Last Modified: | 17 Oct 2019 12:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/9985 |
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