Items where Author is "Abken, Hinrich"

Article

Aleksandrova, Krasimira and Leise, Jana and Priesner, Christoph and Aktas, Murat and Apel, Michael and Assenmacher, Mario and Buerger, Iris and Richter, Anne and Altefrohne, Pia and Schubert, Christine and Holzinger, Astrid and Barden, Markus and Bezler, Valerie and von Bergwelt-Baildon, Michael and Borchmann, Peter and Goudeva, Lilia and Glienke, Wolfgang and Arseniev, Lubomir and Esser, Ruth and Abken, Hinrich and Koehl, Ulrike (2024) °Automated manufacturing and characterization of clinical grade autologous CD20 CAR T cells for the treatment of patients with stage III/IV melanoma. FRONTIERS IN IMMUNOLOGY, 15: 1328368. ISSN 1664-3224,

Harrer, Dennis Christoph and Eder, Matthias and Barden, Markus and Pan, Hong and Herr, Wolfgang and Abken, Hinrich (2024) Ectopic PU.1 Expression Provides Chimeric Antigen Receptor (CAR) T Cells with Innate Cell Capacities Including IFN-β Release. CANCERS, 16 (15): 2737. ISSN , 2072-6694

Kath, Jonas and Franke, Clemens and Drosdek, Vanessa and Du, Weijie and Glaser, Viktor and Fuster-Garcia, Carla and Stein, Maik and Zittel, Tatiana and Schulenberg, Sarah and Porter, Caroline E. and Andersch, Lena and Kuenkele, Annette and Alcaniz, Joshua and Hoffmann, Jens and Abken, Hinrich and Abou-el-Enein, Mohamed and Pruss, Axel and Suzuki, Masataka and Cathomen, Toni and Stripecke, Renata and Volk, Hans-Dieter and Reinke, Petra and Schmueck-Henneresse, Michael and Wagner, Dimitrios L. (2024) Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells. BLOOD, 143 (25). pp. 2599-2611. ISSN 0006-4971, 1528-0020

Harrer, Dennis Christoph and Li, Sin-Syue and Kaljanac, Marcell and Bezler, Valerie and Barden, Markus and Pan, Hong and Herr, Wolfgang and Abken, Hinrich (2024) Magnetic CAR T cell purification using an anti-G4S linker antibody. JOURNAL OF IMMUNOLOGICAL METHODS, 528: 113667. ISSN 0022-1759, 1872-7905

Fischer-Riepe, Lena and Kailayangiri, Sareetha and Zimmermann, Katharina and Pfeifer, Rita and Aigner, Michael and Altvater, Bianca and Kretschmann, Sascha and Voelkl, Simon and Hartley, Jordan and Dreger, Celine and Petry, Katja and Bosio, Andreas and von Doellen, Angelika and Hartmann, Wolfgang and Lode, Holger and Goerlich, Dennis and Mackensen, Andreas and Jungblut, Melanie and Schambach, Axel and Abken, Hinrich and Rossig, Claudia (2024) Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers. CLINICAL CANCER RESEARCH, 30 (16). pp. 3564-3577. ISSN 1078-0432, 1557-3265

Abken, Hinrich (2024) Transforming the Dark into Light: A Siglec-9 Switch. CANCER IMMUNOLOGY RESEARCH, 12 (10). p. 1310. ISSN 2326-6066, 2326-6074

Delacher, Michael and Schmidleithner, Lisa and Simon, Malte and Stueve, Philipp and Sanderink, Lieke and Hotz-Wagenblatt, Agnes and Wuttke, Marina and Schambeck, Kathrin and Ruhland, Brigitte and Hofmann, Veronika and Bittner, Sebastian and Ritter, Uwe and Pant, Asmita and Helbich, Sara Salome and Voss, Morten and Lemmermann, Niels A. W. and Bessiri-Schake, Lisa and Bohn, Toszka and Eigenberger, Andreas and Menevse, Ayse Nur and Gebhard, Claudia and Strieder, Nicholas and Abken, Hinrich and Rehli, Michael and Huehn, Jochen and Beckhoved, Philipp and Hehlgans, Thomas and Junger, Henrik and Geissler, Edward K. and Prantl, Lukas and Werner, Jens M. and Schmidl, Christian and Brors, Benedikt and Imbusch, Charles D. and Feuerer, Markus (2024) The effector program of human CD8 T cells supports tissue remodeling. JOURNAL OF EXPERIMENTAL MEDICINE, 221 (2): e20230488. ISSN 0022-1007, 1540-9538

Thomas, Simone and Abken, Hinrich (2023) CAR T cell therapy becomes CHIC: "cytokine help intensified CAR" T cells. FRONTIERS IN IMMUNOLOGY, 13: 1090959. ISSN 1664-3224,

Altvater, Bianca and Kailayangiri, Sareetha and Spurny, Christian and Fluegge, Maike and Meltzer, Jutta and Greune, Lea and Urban, Katja and Schwoeppe, Christian and Brand, Caroline and Schliemann, Christoph and Hintelmann, Heike and Harrach, Saliha and Hartmann, Wolfgang and Abken, Hinrich and Kuehle, Johannes and Schambach, Axel and Goerlich, Dennis and Berdel, Wolfgang E. and Rossig, Claudia (2023) CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process. CANCER GENE THERAPY, 30 (10). pp. 1355-1368. ISSN 0929-1903, 1476-5500

Barden, Markus and Holzinger, Astrid and Velas, Lukas and Mezosi-Csaplar, Marianna and Szoeor, Arpad and Vereb, Gyoergy and Schuetz, Gerhard J. and Hombach, Andreas A. and Abken, Hinrich (2023) CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation. FRONTIERS IN IMMUNOLOGY, 14: 1110482. ISSN 1664-3224,

Hombach, Andreas A. and Ambrose, Christine and Lobb, Roy and Rennert, Paul and Abken, Hinrich (2023) A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2<SUP>+</SUP> Solid Cancer. CELLS, 12 (2): 248. ISSN , 2073-4409

Ciulean, Ioana Sonya and Fischer, Joe and Quaiser, Andrea and Bach, Christoph and Abken, Hinrich and Tretbar, Uta Sandy and Fricke, Stephan and Koehl, Ulrike and Schmiedel, Dominik and Grunwald, Thomas (2023) CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma. FRONTIERS IN IMMUNOLOGY, 14: 1290488. ISSN 1664-3224,

Harrer, Dennis Christoph and Li, Sin-Syue and Kaljanac, Marcell and Barden, Markus and Pan, Hong and Abken, Hinrich (2023) Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges. FRONTIERS IN IMMUNOLOGY, 14: 1321596. ISSN 1664-3224,

Harrer, Dennis Christoph and Bezler, Valerie and Hartley, Jordan and Herr, Wolfgang and Abken, Hinrich (2023) IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities. FRONTIERS IN IMMUNOLOGY, 14: 1185618. ISSN 1664-3224,

Soto, Karla E. G. and Loureiro, Liliana R. and Bartsch, Tabea and Arndt, Claudia and Kegler, Alexandra and Mitwasi, Nicola and Drewitz, Laura and Hoffmann, Lydia and Saleh, Haidy A. and Crespo, Eugenia and Mehnert, Maria and Daglar, Cansu and Abken, Hinrich and Momburg, Frank and Bachmann, Michael and Feldmann, Anja (2023) Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells. FRONTIERS IN IMMUNOLOGY, 14: 1302354. ISSN 1664-3224,

Harrer, Dennis Christoph and Schenkel, Charlotte and Bezler, Valerie and Kaljanac, Marcell and Hartley, Jordan and Barden, Markus and Pan, Hong and Holzinger, Astrid and Herr, Wolfgang and Abken, Hinrich (2022) CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop. CELLS, 11 (23): 3839. ISSN , 2073-4409

Harrer, Dennis Christoph and Schenkel, Charlotte and Berking, Carola and Herr, Wolfgang and Abken, Hinrich and Doerrie, Jan and Schaft, Niels (2022) Decitabine-Mediated Upregulation of CSPG4 in Ovarian Carcinoma Cells Enables Targeting by CSPG4-Specific CAR-T Cells. CANCERS, 14 (20): 5033. ISSN , 2072-6694

Ormhoj, Maria and Abken, Hinrich and Hadrup, Sine R. (2022) Engineering T-cells with chimeric antigen receptors to combat hematological cancers: an update on clinical trials. CANCER IMMUNOLOGY IMMUNOTHERAPY, 71 (10). pp. 2301-2311. ISSN 0340-7004, 1432-0851

Paasch, Daniela and Meyer, Johann and Stamopoulou, Andriana and Lenz, Daniela and Kuehle, Johannes and Kloos, Doreen and Buchegger, Theresa and Holzinger, Astrid and Falk, Christine S. and Kloth, Christina and von Kaisenberg, Constantin S. and Abken, Hinrich and Schambach, Axel and Lachmann, Nico and Morgan, Michael and Moritz, Thomas (2022) Ex Vivo Generation of CAR Macrophages from Hematopoietic Stem and Progenitor Cells for Use in Cancer Therapy. CELLS, 11 (6): 994. ISSN , 2073-4409

Balta, Emre and Janzen, Nina and Kirchgessner, Henning and Toufaki, Vasiliki and Orlik, Christian and Liang, Jie and Lairikyengbam, Divya and Abken, Hinrich and Niesler, Beate and Mueller-Decker, Karin and Ruppert, Thomas and Samstag, Yvonne (2022) Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment. FRONTIERS IN IMMUNOLOGY, 13: 1063313. ISSN 1664-3224,

Hombach, Andreas and Barden, Markus and Hannappel, Lisa and Chmielewski, Markus and Rappl, Gunter and Sachinidis, Agapios and Abken, Hinrich (2022) IL12 integrated into the CAR exodomain converts CD8(+) T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors. MOLECULAR THERAPY, 30 (2). pp. 593-605. ISSN 1525-0016, 1525-0024

Garofano, Francesca and Sharma, Amit and Abken, Hinrich and Gonzalez-Carmona, Maria A. and Schmidt-Wolf, Ingo G. H. (2022) A Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic Function of CIK Cells without Exerting the Downstream Mediators in Pancreatic Cancer Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (7): 3783. ISSN 1422-0067

Blokon-Kogan, Dayana and Levi-Mann, Maya and Malka-Levy, Lior and Itzhaki, Orit and Besser, Michal J. and Shiftan, Yuval and Szoor, Arpad and Vereb, Gyorgy and Gross, Gideon and Abken, Hinrich and Weinstein-Marom, Hadas (2022) Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 10 (9): e001544. ISSN , 2051-1426

Ambrose, Christine and Su, Lihe and Wu, Lan and Dufort, Fay J. and Sanford, Thomas and Birt, Alyssa and Hackel, Benjamin J. and Hombach, Andreas and Abken, Hinrich and Lobb, Roy R. and Rennert, Paul D. (2021) Anti-CD19 CAR T cells potently redirected to kill solid tumor cells. PLOS ONE, 16 (3): e0247701. ISSN 1932-6203,

Koehl, Ulrike and Abken, Hinrich (2021) CAR T cells as drugs for novel therapies (advanced therapy medicinal products). INTERNIST, 62 (4). pp. 449-457. ISSN 0020-9554, 1432-1289

Bunse, Mario and Pfeilschifter, Janina and Bluhm, Julia and Zschummel, Maria and Joedicke, Jara J. and Wirges, Anthea and Stark, Helen and Kretschmer, Vivien and Chmielewski, Markus and Uckert, Wolfgang and Abken, Hinrich and Westermann, Joerg and Rehm, Armin and Hoepken, Uta E. (2021) CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells. NATURE COMMUNICATIONS, 12 (1): 240. ISSN 2041-1723

Holzinger, A. and Abken, Hinrich (2021) Chimeric antigen receptors (CARs): universal tools in adoptive cell therapy. ONKOLOGE, 27 (11). pp. 1069-1074. ISSN 0947-8965, 1433-0415

Holzinger, A. and Abken, Hinrich (2021) Chimeric antigen receptors (CARs): universal tools in adoptive cell therapy. INTERNIST, 62 (6). pp. 583-588. ISSN 0020-9554, 1432-1289

Rudek, Loreen Sophie and Zimmermann, Katharina and Galla, Melanie and Meyer, Johann and Kuehle, Johannes and Stamopoulou, Andriana and Brand, Daniel and Sandalcioglu, I. Erol and Neyazi, Belal and Moritz, Thomas and Rossig, Claudia and Altvater, Bianca and Falk, Christine S. and Abken, Hinrich and Morgan, Michael Alexander and Schambach, Axel (2021) Generation of an NF kappa B-Driven Alpharetroviral "All-in-One" Vector Construct as a Potent Tool for CAR NK Cell Therapy. FRONTIERS IN IMMUNOLOGY, 12: 751138. ISSN 1664-3224,

Dragon, Anna Christina and Zimmermann, Katharina and Nerreter, Thomas and Sandfort, Deborah and Lahrberg, Julia and Kloss, Stephan and Kloth, Christina and Mangare, Caroline and Bonifacius, Agnes and Tischer-Zimmermann, Sabine and Blasczyk, Rainer and Maecker-Kolhoff, Britta and Uchanska-Ziegler, Barbara and Abken, Hinrich and Schambach, Axel and Hudecek, Michael and Eiz-Vesper, Britta (2020) CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 8 (2): e000736. ISSN 2051-1426

Nemade, Harshal and Acharya, Aviseka and Chaudhari, Umesh and Nembo, Erastus and Nguemo, Filomain and Riet, Nicole and Abken, Hinrich and Hescheler, Juergen and Papadopoulos, Symeon and Sachinidis, Agapios (2020) Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells. CELLS, 9 (3): 554. ISSN 2073-4409

Zimmermann, Katharina and Kuehle, Johannes and Dragon, Anna Christina and Galla, Melanie and Kloth, Christina and Rudek, Loreen Sophie and Sandalcioglu, I. Erol and Neyazi, Belal and Moritz, Thomas and Meyer, Johann and Rossig, Claudia and Altvater, Bianca and Eiz-Vesper, Britta and Morgan, Michael Alexander and Abken, Hinrich and Schambach, Axel (2020) Design and Characterization of an "All-in-One" Lentiviral Vector System Combining Constitutive Anti-G(D2) CAR Expression and Inducible Cytokines. CANCERS, 12 (2): 375. ISSN 2072-6694

Patasic, Lea and Seifried, Janna and Bezler, Valerie and Kaljanac, Marcell and Schneider, Irene C. and Schmitz, Heike and Tondera, Christiane and Hartmann, Jessica and Hombach, Andreas and Buchholz, Christian J. and Abken, Hinrich and Koenig, Renate and Cichutek, Klaus (2020) Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4(+)T cells to reduce the latent HIV(+)cell reservoir. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 209 (6). pp. 681-691. ISSN 0300-8584, 1432-1831

Hombach, Andreas A. and Geumann, Ulf and Guenther, Christine and Hermann, Felix G. and Abken, Hinrich (2020) IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells. CELLS, 9 (4): 873. ISSN 2073-4409

Haumann, Sophie and Boix, Julia and Knuever, Jana and Bieling, Angela and Vila Sanjurjo, Anton and Elson, Joanna L. and Blakely, Emma L. and Taylor, Robert W. and Riet, Nicole and Abken, Hinrich and Kashkar, Hamid and Hue-Tran Hornig-Do, and Wiesner, Rudolf J. (2020) Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells. CARCINOGENESIS, 41 (12). pp. 1735-1745. ISSN 0143-3334, 1460-2180

Alzubi, Jamal and Dettmer-Monaco, Viviane and Kuehle, Johannes and Thorausch, Niko and Seidl, Maximilian and Taromi, Sanaz and Schamel, Wolfgang and Zeiser, Robert and Abken, Hinrich and Cathomen, Toni and Wolf, Philipp (2020) PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model. MOLECULAR THERAPY-ONCOLYTICS, 18. pp. 226-235. ISSN 2372-7705

Toth, Gabor and Szollosi, Janos and Abken, Hinrich and Vereb, Gyorgy and Szoor, Arpad (2020) A Small Number of HER2 Redirected CAR T Cells Significantly Improves Immune Response of Adoptively Transferred Mouse Lymphocytes against Human Breast Cancer Xenografts. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (3): 1039. ISSN 1422-0067

Szoor, Arpad and Toth, Gabor and Zsebik, Barbara and Szabo, Viktoria and Eshhar, Zelig and Abken, Hinrich and Vereb, Gyorgy (2020) Trastuzumab derived HER2-specific CARs for the treatment of trastuzumab-resistant breast cancer: CAR T cells penetrate and eradicate tumors that are not accessible to antibodies. CANCER LETTERS, 484. pp. 1-8. ISSN 0304-3835, 1872-7980

Hombach, Andreas A. and Rappl, Gunter and Abken, Hinrich (2019) Blocking CD30 on T Cells by a Dual Specific CAR for CD30 and Colon Cancer Antigens Improves the CAR T Cell Response against CD30(-) Tumors. MOLECULAR THERAPY, 27 (10). pp. 1825-1835. ISSN 1525-0016, 1525-0024

Chmielewski, Markus and Kuehle, Johannes and Chrobok, Danuta and Riet, Nicole and Hallek, Michael and Abken, Hinrich (2019) FimH-based display of functional eukaryotic proteins on bacteria surfaces. SCIENTIFIC REPORTS, 9: UNSP 8410. ISSN 2045-2322

Aleksandrova, Krasimira and Leise, Jana and Priesner, Christoph and Melk, Anette and Kubaink, Fanni and Abken, Hinrich and Hombach, Andreas and Aktas, Murat and Essl, Mike and Buerger, Iris and Kaiser, Andrew and Rauser, Georg and Jurk, Marion and Goudeva, Lilia and Glienke, Wolfgang and Arseniev, Lubomir and Esser, Ruth and Koehl, Ulrike (2019) Functionality and Cell Senescence of CD4/CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy (R) Platform. TRANSFUSION MEDICINE AND HEMOTHERAPY, 46 (1). pp. 47-54. ISSN 1660-3796, 1660-3818

Golumba-Nagy, Viktoria and Kuehle, Johannes and Hombach, Andreas A. and Abken, Hinrich (2018) CD28-zeta CAR T Cells Resist TGF-beta Repression through IL-2 Signaling, Which Can Be Mimicked by an Engineered IL-7 Autocrine Loop. MOLECULAR THERAPY, 26 (9). pp. 2218-2230. ISSN 1525-0016, 1525-0024

Probst, Kristina and Stermann, Jacek and von Bomhard, Inga and Etich, Julia and Pitzler, Lena and Niehoff, Anja and Bluhm, Bjoern and Xu, Haifeng C. and Lang, Philipp A. and Chmielewski, Markus and Abken, Hinrich and Blissenbach, Birgit and Machova, Alzbeta and Papadopoulou, Nikoletta and Brachvogel, Bent (2018) Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function. STEM CELLS, 36 (11). pp. 1752-1763. ISSN 1066-5099, 1549-4918

Conference or Workshop Item

Dragon, Anna Christina and Zimmermann, Katharina and Nerreter, Thomas and Sandfort, Deborah and Lahrberg, Julia and Kloess, Stephan and Kloth, Christina and Mangare, Caroline and Bonifacius, Agnes and Tischer-Zimmermann, Sabine and Blasczyk, Rainer and Maecker-Kolhoff, Britta and Abken, Hinrich and Schambach, Axel and Hudecek, Michael and Eiz-Vesper, Britta (2020) PEPTIDE-SPECIFIC CAR-T CELLS AND TRUCKS WITH INDUCIBLE IL-12 EXPRESSION CONTROL EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOPROLIFERATION. In: 34th European Immunogenetics and Histocompatibility and 31st British Society for Histocompatibility and Immunogenetics Conference, April 26 - 29, 2020, Glasgow, Scotland, United Kingdom.

Other

Kaljanac, Marcell and Abken, Hinrich (2023) Do Treg Speed Up with CARs? Chimeric Antigen Receptor Treg Engineered to Induce Transplant Tolerance. LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA.

Hartley, Jordan and Abken, Hinrich (2019) Chimeric antigen receptors designed to overcome transforming growth factor-beta-mediated repression in the adoptive T-cell therapy of solid tumors. WILEY, HOBOKEN.