Items where Author is "Strasser, Andrea"

Article

Tropmann, Katharina and Bresinsky, Merlin and Forster, Lisa and Moennich, Denise and Buschauer, Armin and Wittmann, Hans-Joachim and Huebner, Harald and Gmeiner, Peter and Pockes, Steffen and Strasser, Andrea (2021) Abolishing Dopamine D-2long/D-3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H-2 Receptor Agonists. JOURNAL OF MEDICINAL CHEMISTRY, 64 (12). pp. 8684-8709. ISSN 0022-2623, 1520-4804

Seibel-Ehlert, Ulla and Plank, Nicole and Inoue, Asuka and Bernhardt, Guenther and Strasser, Andrea (2021) Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (18): 9739. ISSN 1422-0067

Tropmann, Katharina and Seibel-Ehlert, Ulla and Littmann, Timo and Strasser, Andrea (2021) Shining light on the histamine H-2 receptor: Synthesis of carbamoylguanidine-type agonists as a pharmacological tool to study internalization. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 52: 128388. ISSN 0960-894X, 1464-3405

Hoering, Carina and Conrad, Marcus and Soldner, Christian A. and Wang, Jinan and Sticht, Heinrich and Strasser, Andrea and Miao, Yinglong (2021) Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (18): 10047. ISSN , 1422-0067

Horing, Carina and Seibel, Ulla and Tropmann, Katharina and Gratz, Lukas and Monnich, Denise and Pitzl, Sebastian and Bernhardt, Gunther and Pockes, Steffen and Strasser, Andrea (2020) A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (22): 8440. ISSN 1422-0067

Dolles, Dominik and Hoffmann, Matthias and Gunesch, Sandra and Marinelli, Oliviero and Moeller, Jan and Santoni, Giorgio and Chatonnet, Arnaud and Lohse, Martin J. and Wittmann, Hans Joachim and Strasser, Andrea and Nabissi, Massimo and Maurice, Tangui and Decker, Michael (2018) Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles. JOURNAL OF MEDICINAL CHEMISTRY, 61 (4). pp. 1646-1663. ISSN 0022-2623, 1520-4804

Wittmann, Hans-Joachim and Strasser, Andrea (2017) Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions? NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 390 (6). pp. 595-612. ISSN 0028-1298, 1432-1912

Hammer, Sebastian G. and Gobleder, Susanne and Naporra, Franziska and Wittmann, Hans-Joachim and Elz, Sigurd and Heinrich, Markus R. and Strasser, Andrea (2016) 2,4-Diaminopyrimidines as dual ligands at the histamine H-1 and H-4 receptor-H-1/H-4-receptor selectivity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26 (2). pp. 292-300. ISSN 0960-894X, 1464-3405

Dolles, Dominik and Nimczick, Martin and Scheiner, Matthias and Ramler, Jacqueline and Stadtmueller, Patricia and Sawatzky, Edgar and Drakopoulos, Antonios and Sotriffer, Christoph and Wittmann, Hans-Joachim and Strasser, Andrea and Decker, Michael (2016) Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB(2)R Ligands To Combat Neurodegenerative Disorders. CHEMMEDCHEM, 11 (12). pp. 1270-1283. ISSN 1860-7179, 1860-7187

Geyer, Roland and Nordemann, Uwe and Strasser, Andrea and Wittmann, Hans-Joachim and Buschauer, Armin (2016) Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H-4 Receptor Agonists. JOURNAL OF MEDICINAL CHEMISTRY, 59 (7). pp. 3452-3470. ISSN 0022-2623, 1520-4804

Naporra, Franziska and Gobleder, Susanne and Wittmann, Hans Joachim and Spindler, Julia and Bodensteiner, Michael and Bernhardt, Guenther and Huebner, Harald and Gmeiner, Peter and Elz, Sigurd and Strasser, Andrea (2016) Dibenzo[bf][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs. PHARMACOLOGICAL RESEARCH, 113. pp. 610-625. ISSN 1043-6618

Wittmann, Hans-Joachim and Strasser, Andrea (2015) Binding pathway of histamine to the hH(4)R, observed by unconstrained molecular dynamics. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25 (6). pp. 1259-1268. ISSN 0960-894X, 1464-3405

Kirchhof, Susanne and Strasser, Andrea and Wittmann, Hans-Joachim and Messmann, Viktoria and Hammer, Nadine and Goepferich, Achim M. and Brandl, Ferdinand P. (2015) New insights into the cross-linking and degradation mechanism of Diels-Alder hydrogels. JOURNAL OF MATERIALS CHEMISTRY B, 3 (3). pp. 449-457. ISSN 2050-750X, 2050-7518

Untergehrer, Monika and Buecherl, Daniel and Wittmann, Hans-Joachim and Strasser, Andrea and Heilmann, Joerg and Juergenliemk, Guido (2015) Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human beta-Glucuronidase - In Vitro and In Silico Analyses. PLANTA MEDICA, 81 (12-13). pp. 1182-1189. ISSN 0032-0943, 1439-0221

Cuboni, Serena and Devigny, Christian and Hoogeland, Bastiaan and Strasser, Andrea and Pomplun, Sebastian and Hauger, Barbara and Hoefner, Georg and Wanner, Klaus T. and Eder, Matthias and Buschauer, Armin and Holsboer, Florian and Hausch, Felix (2014) Loratadine and Analogues: Discovery and Preliminary Structure-Activity Relationship of Inhibitors of the Amino Acid Transporter B(0)AT2. JOURNAL OF MEDICINAL CHEMISTRY, 57 (22). pp. 9473-9479. ISSN 0022-2623, 1520-4804

Wagner, Eva and Wittmann, Hans-Joachim and Elz, Sigurd and Strasser, Andrea (2014) Pharmacological profile of astemizole-derived compounds at the histamine H-1 and H-4 receptor-H-1/H-4 receptor selectivity. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 387 (3). pp. 235-250. ISSN 0028-1298, 1432-1912

Wittmann, Hans-Joachim and Seifert, Roland and Strasser, Andrea (2014) Sodium binding to hH(3)R and hH(4)R - a molecular modeling study. JOURNAL OF MOLECULAR MODELING, 20 (8): 2394. ISSN 1610-2940, 0948-5023

Darras, Fouad H. and Pockes, Steffen and Huang, Guozhenz and Wehle, Sarah and Strasser, Andrea and Wittmann, Hans-Joachim and Nimczick, Martin and Sotriffer, Christoph A. and Decker, Michael (2014) Synthesis, Biological Evaluation, and Computational Studies of Tri- and Tetracyclic Nitrogen-Bridgehead Compounds as Potent Dual-Acting AChE Inhibitors and hH(3) Receptor Antagonists. ACS CHEMICAL NEUROSCIENCE, 5 (3). pp. 225-242. ISSN 1948-7193

Strasser, Andrea and Wittmann, Hans-Joachim (2013) Molecular modeling studies give hint for the existence of a symmetric h beta R-2-G alpha beta gamma-homodimer. JOURNAL OF MOLECULAR MODELING, 19 (10). pp. 4443-4457. ISSN 1610-2940, 0948-5023

Appl, Heidrun and Holzammer, Tobias and Dove, Stefan and Haen, Ekkehard and Strasser, Andrea and Seifert, Roland (2012) Interactions of recombinant human histamine H-1, H-2, H-3, and H-4 receptors with 34 antidepressants and antipsychotics. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 385 (2). pp. 145-170. ISSN 0028-1298, 1432-1912

Wittmann, Hans-Joachim and Seifert, Roland and Strasser, Andrea (2011) Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H1R. BIOCHEMICAL PHARMACOLOGY, 82 (12). pp. 1910-1918. ISSN 0006-2952

Wagner, Eva and Wittmann, Hans-Joachim and Elz, Sigurd and Strasser, Andrea (2011) Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21 (21). pp. 6274-6280. ISSN 0960-894X

Wittmann, Hans-Joachim and Elz, Sigurd and Seifert, Roland and Strasser, Andrea (2011) N (alpha)-Methylated phenylhistamines exhibit affinity to the hH(4)R-a pharmacological and molecular modelling study. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 384 (3). pp. 287-299. ISSN 0028-1298, 1432-1912

Ferstl, Matthias and Strasser, Andrea and Wittmann, Hans-Joachim and Drechsler, Markus and Rischer, Matthias and Engel, Juergen and Goepferich, Achim (2011) Nanofibers Resulting from Cooperative Electrostatic and Hydrophobic Interactions between Peptides and Polyelectrolytes of Opposite Charge. LANGMUIR, 27 (23). pp. 14450-14459. ISSN 0743-7463

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical Stimulatory Effects of the "Standard" Histamine H-4-Receptor Antagonist JNJ7777120: the H-4 Receptor Joins the Club of 7 Transmembrane Domain Receptors Exhibiting Functional Selectivity. MOLECULAR PHARMACOLOGY, 79 (4). pp. 631-638. ISSN 0026-895X, 1521-0111

Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H-4 receptor in receptor activation. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 384 (3). pp. 301-317. ISSN 0028-1298

Silva, Maria Elena and Heim, Ralf and Strasser, Andrea and Elz, Sigurd and Dove, Stefan (2011) Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 25 (1). pp. 51-66. ISSN 0920-654X

Strasser, Andrea and Wittmann, Hans-Joachim (2010) 3D-QSAR CoMFA Study to Predict Orientation of Suprahistaprodifens and Phenoprodifens in the Binding-Pocket of Four Histamine H-1-Receptor Species. MOLECULAR INFORMATICS, 29 (4). pp. 333-341. ISSN 1868-1743

Schnell, David and Strasser, Andrea and Seifert, Roland (2010) Comparison of the pharmacological properties of human and rat histamine H-3-receptors. BIOCHEMICAL PHARMACOLOGY, 80 (9). pp. 1437-1449. ISSN 0006-2952

Strasser, Andrea and Wittmann, Hans-Joachim (2010) Distinct interactions between the human adrenergic beta(2) receptor and G alpha(s)-an in silico study. JOURNAL OF MOLECULAR MODELING, 16 (8). pp. 1307-1318. ISSN 1610-2940

Schneider, Erich H. and Schnell, David and Strasser, Andrea and Dove, Stefan and Seifert, Roland (2010) Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 333 (2). pp. 382-392. ISSN 0022-3565

Strasser, Andrea and Wittmann, Hans-Joachim (2010) In silico analysis of the histaprodifen induced activation pathway of the guinea-pig histamine H-1-receptor. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 24 (9). pp. 759-769. ISSN 0920-654X, 1573-4951

Schneider, Erich H. and Strasser, Andrea and Thurmond, Robin L. and Seifert, Roland (2010) Structural Requirements for Inverse Agonism and Neutral Antagonism of Indole-, Benzimidazole-, and Thienopyrrole-Derived Histamine H-4 Receptor Ligands. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 334 (2). pp. 513-521. ISSN 0022-3565, 1521-0103

Wittmann, Hans-Joachim and Seifert, Roland and Strasser, Andrea (2009) Contribution of Binding Enthalpy and Entropy to Affinity of Antagonist and Agonist Binding at Human and Guinea Pig Histamine H-1-Receptor. MOLECULAR PHARMACOLOGY, 76 (1). pp. 25-37. ISSN 0026-895X, 1521-0111

Deml, Karl-Friedrich and Beermann, Silke and Neumann, Detlef and Strasser, Andrea and Seifert, Roland (2009) Interactions of Histamine H-1-Receptor Agonists and Antagonists with the Human Histamine H-4-Receptor. MOLECULAR PHARMACOLOGY, 76 (5). pp. 1019-1030. ISSN 0026-895X

Strasser, Andrea and Wittmann, Hans-Joachim and Kunze, Marc and Elz, Sigurd and Seifert, Roland (2009) Molecular Basis for the Selective Interaction of Synthetic Agonists with the Human Histamine H-1-Receptor Compared with the Guinea Pig H-1-Receptor. MOLECULAR PHARMACOLOGY, 75 (3). pp. 454-465. ISSN 0026-895X

Igel, Patrick and Geyer, Roland and Strasser, Andrea and Dove, Stefan and Seifert, Roland and Buschauer, Armin (2009) Synthesis and Structure-Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H-4 Receptor Agonists. JOURNAL OF MEDICINAL CHEMISTRY, 52 (20). pp. 6297-6313. ISSN 0022-2623, 1520-4804

Strasser, Andrea and Wittmann, Hans-Joachim and Seifert, Roland (2008) Ligand-specific contribution of the N terminus and E2-loop to pharmacological properties of the histamine H(1)-receptor. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 326 (3). pp. 783-791. ISSN 0022-3565

Strasser, Andrea and Striegl, Birgit and Wittmann, Hans-Joachim and Seifert, Roland (2008) Pharmacological profile of histaprodifens at four recombinant histamine H-1 receptor species isoforms. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 324 (1). pp. 60-71. ISSN 0022-3565

Strasser, Andrea and Wittmann, Hans-Joachim (2007) Analysis of the activation mechanism of the guinea-pig Histamine H-1-receptor. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 21 (9). pp. 499-509. ISSN 0920-654X, 1573-4951

Strasser, Andrea and Wittmann, Hans-Joachim (2007) LigPath: a module for predictive calculation of a ligand's pathway into a receptor-application to the gpH(1)-receptor. JOURNAL OF MOLECULAR MODELING, 13 (1). pp. 209-218. ISSN 1610-2940

Pertz, Heinz H. and Gornemann, Tilo and Schurad, Bjoern and Seifert, Roland and Strasser, Andrea (2006) Striking differences of action of lisuride stereoisomers at histamine H-1 receptors. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 374 (3). pp. 215-222. ISSN 0028-1298, 1432-1912

Conference or Workshop Item

Hoering, Carina and Seibel, Ulla and Littmann, Timo and Graetz, Lukas and Strasser, Andrea and Bernhardt, Guenther (2020) A MiniG Protein Recruitment Assay for the Histamine Receptor Family to Functionally Characterize Histamine Receptor Ligands. In: Annual Meeting on Experimental Biology, APR 04-07, 2020, San Diego, CA.

Other

Dolles, Dominik and Sawatzky, Edgar and Moeller, Jan and Nabissi, Massimo and Drakopoulos, Antonios and Strasser, Andrea and Wittmann, Hans-Joachim and Lohse, Martin and Decker, Michael (2017) Aminobenzimidazoles and structural isomers: Design, synthesis, pharmacological evaluation and computational studies of novel dual-acting butyrylcholinesterase inhibitors and hCB2 receptor ligands for the treatment of Alzheimer's disease. AMER CHEMICAL SOC, WASHINGTON.

Strasser, Andrea and Wittmann, Hans-Joachim and Seifert, Roland (2017) Binding Kinetics and Pathways of Ligands to GPCRs. ELSEVIER SCIENCE LONDON, LONDON.

Strasser, Andrea and Wittmann, Hans-Joachim and Schneider, Erich H. and Seifert, Roland (2015) Modulation of GPCRs by monovalent cations and anions. SPRINGER, NEW YORK.

Seifert, Roland and Strasser, Andrea and Schneider, Erich H. and Neumann, Detlef and Dove, Stefan and Buschauer, Armin (2013) Molecular and cellular analysis of human histamine receptor subtypes. ELSEVIER SCIENCE LONDON, LONDON.

Strasser, Andrea and Wittmann, Hans-Joachim and Buschauer, Armin and Schneider, Erich H. and Seifert, Roland (2013) Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs. ELSEVIER SCIENCE LONDON, LONDON.