Sarubin, Nina and Hilbert, Sven and Naumann, Felix and Zill, Peter and Wimmer, Anna-Maria and Nothdurfter, Caroline and Rupprecht, Rainer and Baghai, Thomas C. and Buehner, Markus and Schuele, Cornelius (2017) The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 267 (2). pp. 123-133. ISSN 0940-1334, 1433-8491
Full text not available from this repository. (Request a copy)Abstract
Genetic variations in the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) have been associated with maladaptive stress responses and major depressive disorder (MDD). In a case-control study design, we examined whether single nucleotide polymorphisms (SNPs) and haploid genotype (haplotype) associations of MR gene NR3C2, GR gene NR3C1 and genes of GR chaperone molecules FK506 binding protein 5 (FKBP5) and corticotrophin-releasing hormone receptor 1 (CRHR1) differed between healthy subjects (n = 634) and inpatients with major depressive disorder (n = 412). All analyses were conducted for women and men separately. After conservative correction of Type-I-error to obtain reliable p values, one SNP in the NR3C1 gene, namely rs6195, showed a significant association with the presence of a major depression (p = 0.048) in females. In contrast, NR3C2, FKBP5 and CRHR1 polymorphisms were not significantly associated with MDD. No haplotype effects could be identified. Our results support the notion of an association between variants of GR-related genes in women and the pathophysiology of depression: females suffering from MDD showed a more than three times higher frequency of the T/C polymorphism compared to controls, which thus seems to increase the vulnerability to depression in females.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MINERALOCORTICOID RECEPTOR; HORMONE-RECEPTOR; TREATMENT RESPONSE; CRHR1 GENE; ANTIDEPRESSANT TREATMENT; CHILDHOOD MALTREATMENT; ADULT DEPRESSION; MOOD DISORDERS; STRESS; POLYMORPHISMS; Depression; Genetic variations; HPA axis; NR3C1 |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 300 Social sciences > 370 Education |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie Psychology and Pedagogy > Institut für Pädagogik Psychology and Pedagogy > Institut für Sportwissenschaft |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 14 Feb 2019 15:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/325 |
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