Jansma, J. Martijn and Rutten, Geert-Jan and Ramsey, Lenny E. and Snijders, T. J. and Bizzi, Alberto and Rosengarth, Katharina and Dodoo-Schittko, Frank and Hattingen, Elke and de la Pena, Mar Jimenez and von Campe, Gord and Jehna, Margit and Ramsey, Nick F. (2020) Automatic identification of atypical clinical fMRI results. NEURORADIOLOGY, 62 (12). pp. 1677-1688. ISSN 0028-3940, 1432-1920
Full text not available from this repository. (Request a copy)Abstract
Purpose Functional MRI is not routinely used for neurosurgical planning despite potential important advantages, due to difficulty of determining quality. We introduce a novel method for objective evaluation of fMRI scan quality, based on activation maps. A template matching analysis (TMA) is presented and tested on data from two clinical fMRI protocols, performed by healthy controls in seven clinical centers. Preliminary clinical utility is tested with data from low-grade glioma patients. Methods Data were collected from 42 healthy subjects from seven centers, with standardized finger tapping (FT) and verb generation (VG) tasks. Copies of these "typical" data were deliberately analyzed incorrectly to assess feasibility of identifying them as "atypical." Analyses of the VG task administered to 32 tumor patients assessed sensitivity of the TMA method to anatomical abnormalities. Results TMA identified all atypical activity maps for both tasks, at the cost of incorrectly classifying 3.6 (VG)-6.5% (FT) of typical maps as atypical. For patients, the average TMA was significantly higher than atypical healthy scans, despite localized anatomical abnormalities caused by a tumor. Conclusion This study supports feasibility of TMA for objective identification of atypical activation patterns for motor and verb generation fMRI protocols. TMA can facilitate the use and evaluation of clinical fMRI in hospital settings that have limited access to fMRI experts. In a clinical setting, this method could be applied to automatically flag fMRI scans showing atypical activation patterns for further investigation to determine whether atypicality is caused by poor scan data quality or abnormal functional topography.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIRECT CORTICAL STIMULATION; FUNCTIONAL MRI; LANGUAGE LATERALIZATION; BRAIN-TUMORS; TEST-RETEST; MOTOR; REPRODUCIBILITY; RELIABILITY; LOCALIZATION; ACTIVATION; Functional MRI; Motor cortex; Language; Brain function; Clinical fMRI |
| Subjects: | 300 Social sciences > 370 Education 400 Language > 400 Language, Linguistics 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin Languages and Literatures > Institut für Information und Medien, Sprache und Kultur (I:IMSK) Languages and Literatures > Institut für Information und Medien, Sprache und Kultur (I:IMSK) > Lehrstuhl für Allgemeine und vergleichende Sprachwissenschaft |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Mar 2021 07:42 |
| Last Modified: | 16 Mar 2021 07:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44010 |
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